Pablo Helguera
Got an idea for a classical cartoon or a reaction to this one? Leave your thoughts in the comments section, on Twitter @nprclassical, or on Facebook at NPR Classical.
Pablo Helguera is a New York-based artist working with sculpture, drawing, photography and performance. His new book is Helguera's Artunes. You can see more of his work at Artworld Salon and on his own site.
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Q. Why did the internet marketer cross the road?
?
A. ?To get to the new shiny object of course.
Lame joke I know?.but accurate nonetheless.
?
Hey, you only need to spend a few minutes
in a niche forum or read the comment section
of blogs and websites to see this is true
of most marketers.
?
You?ll hear their constant droning about how
amaaazing their opportunity is and how unique
(along with all the other ? unique? ones) it is, or
?
how awesome this new ?traffic tool? is,
or ? this is the ultimate SEO ninja software
that can out smart Google?.dribble
dribble, dribble.
?
Sigh.
?
Wannabe marketers(spammers) jumping
like squirrels on crack from one thing to the next
in search of the secret formula, tool or
?
biz opp to make them rich. This is nauseating
stuff.
?
If these marketers would turn from their wicked
ways and focused their ?grey matter on the 3 things
that really matter (good offer, traffic and conversions)
?
they would actually start succeeding (making mullah online).
Revelation! Yes?.you actually can earn good $ online.
?
So my advice to these noob ?marketers??pull ya headz in
and start learning how to market your product/opportunity
properly.
Hey, I know YOU don?t do this?.
?but if you?re still getting little to no results from
all the hours you?re putting in?.Go Here:
?
makemoneyonline.com
Just learn, apply?.cash the checks .
howtomakemoneyonline.com
?
?
Kelvin Dorsey
Kelvin and Bec
Kelvin & Bec Dorsey are from Sydney's Northern Beaches. Running a business and raising 3 children has not hindered them from building a successful online marketing business. They teach ordinary people how to create extra-ordinary income from home using simple online strategies.
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Sorry, Readability was unable to parse this page for content.
Source: http://www.facebook.com/wcybnews5/posts/10151871617733825
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It's one of the most mundane tasks you probably undertake so, if you're anything like me, you probably put off doing your laundry until the absolute last minute. But do astronauts do the same in space?
     |
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Source: fashionscansremastered.net --- Sunday, August 11, 2013
Editorial is entitled, ?Lake Bell?s Tattoo Is Not Real? and is shot by Mark Seliger. Lake Bell also has a (fully clothed) editorial in the September issue of InStyle but since this mag features more gratuitous nudity, I?ll post this ? Continue reading ? ...
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Dynamole is geheel gratis te spelen.
- Gemakkelijk te leren, maar een uitdaging om te beheersen!
- De mogelijkheid met vrienden uit de buurt te spelen, zonder te hoeven aanmelden bij Facebook.
- Verschillende divisies, dus je speelt tegen spelers met een vergelijkbaar niveau.
- Oefenmodus: oefen een paar keer voordat je het opneemt tegen je vrienden!
Hulp je feedback? Heb je help nodig? ajb sturen naar!
Email: support@mantisshrimp.net
A lot of bugs fixed.
Source: http://www.bookmarksurfer.com/showcoll.php?id=5206048537f11
Jacksonville, Fla. ? Jacksonville Jaguars coach Gus Bradley had receiver Justin Blackmon and defensive end Jason Babin in his office Saturday morning, hours after the two got into it on the sideline during the team?s exhibition opener.
Bradley was pleased with what he heard, too.
?I?m not going to say that there was (nothing) between Justin and Jason Babin, but it was more like, ?Just back up when Gus is telling you to back up,?? Bradley said. ?It?s one of those things, and it probably appeared bigger. ? But it was a lot smaller than what I initially thought.?
It started when Blackmon, sitting out because of a groin injury, began jawing with Miami Dolphins cornerback Nolan Carroll in the second quarter. The Jaguars were upset with a tackle and made it known to Carroll. Blackmon was the closest and most vocal of the bunch, escalating the tiff to the point where Bradley took notice.
That?s when veteran defensive end Jason Babin stepped in, apparently telling Blackmon to calm down, which drew a reaction from his teammate. Running back Maurice Jones-Drew eventually calmed Blackmon down and escorted him to the locker room.
?We?re handing it inside the building and trying to move on,? Jones-Drew said.
Blackmon, meanwhile, skipped the team?s open media session Saturday.
Babin, a native of Paw Paw, Mich., near Kalamazoo, downplayed the spat, even reacting to questions as if he was unaware anything happened.
?Just an emotional game,? he said. ?It?s how it?s done, you know? It?s football. Whatever happens Sunday, happens Sunday, and that?s it.?
Jawing with opponents on the field and even arguing with coaches and teammates on the sideline is nothing new. It happens all the time and often gets caught on camera.
This one?s newsworthy because it involved Blackmon, who?s trying to prove he?s matured after two alcohol-related arrests in three years and a four-game suspension handed down in April for violating the league?s substance-abuse policy.
And getting into disputes with opponents and teammates is hardly the way to show he?s growing up.
That?s why Blackmon was in Bradley?s office after the game and again Saturday.
?I just told him to spend time encouraging our guys (rather) than getting caught up in that,? Bradley said after the game, a 27-3 loss to the Dolphins that included four turnovers and many other issues. ?Why add that to the game already? You?re falling into that. That?s not what we want on the sidelines and when I approached him in my office and talked to him about that, he understands, but it still happened.
?We?ll talk about it as a team and say that?s not who we are or what we want to become, so we?ll take it out of our game.?
There was some good news surrounding Blackmon on Saturday.
Bradley said the fifth overall pick in the 2012 draft could be cleared to practice next week. Blackmon has been sidelined since the end June with a groin injury. He has surgery following a mandatory minicamp, has been recovering and opened training camp on the physically unable to perform list.
Rookie safety Johnathan Cyprien, who has missed all of camp with a hamstring injury, also is probable to return.
?That?s two good things right there,? Bradley said. ?We?ll wait and see on Monday, but we feel good about that.?
In other injury news, linebacker Russell Allen was wearing walking boot on his right ankle Saturday, while defensive end Ryan Davis was being evaluated for a possible concussion and tight end Isaiah Stanback was dealing with a quadriceps injury. All three were hurt in the exhibition game.
Rams coach Jeff Fisher said Saturday he has lost a lot of respect for former NFL quarterback Bernie Kosar, who was highly critical of Fisher?s team while serving as color commentator for the Cleveland Browns on Thursday night in the exhibition opener.
The Rams fell behind early and lost, 27-19. Kosar was particularly outspoken about Rams backup quarterback Kellen Clemons, stating at one point, ?I can?t stand watching him play.?
Fisher was asked about Kosar?s comments after the Rams? practice Saturday and did not hold back.
?First off, let me say this: the Cleveland Browns? organization is a first class organization from top to bottom and it has been that for years and years and years,? Fisher said. ?I guess I?m a little disappointed. I feel bad for them that they had someone doing their broadcast feel the need to speak that way about players, specifically on our team and coaches for that matter.
?I?m just surprised that Bernie has such a lack of respect for players and this game. To be honest with you, I lost a lot of respect for him. It?s highly unlikely he knew anything about our football team, but felt the need to make those comments. I don?t think they were justified.?
In particular, Fisher felt Kosar was off base about Clemens, an eight-year pro out of Oregon. Clemens finished the game by completing 6 of 13 passes for 116 with a touchdown and two interceptions.
Chargers rookie linebacker Manti Te?o will sit out this week with a sprained right foot and miss San Diego?s game at Chicago on Thursday.
Te?o wore a walking boot while watching Saturday morning?s practice.
?Manti has a foot sprain and he will be out this week and I will give you any further updates as the week goes on, or next week,? coach Mike McCoy said. ?But he will be out for the week.?
The team refused to make Te?o available to reporters, saying he would speak Monday.
... Bengals receiver Andrew Hawkins will wear a cast for 10 days to try to heal his sprained left ankle, making it doubtful he?ll be ready for the season opener.
Coach Marvin Lewis said Saturday that Hawkins will be evaluated again in 10 days. If he?s not ready for the opener Sept. 8 in Chicago, he could be placed on injured reserve with an opportunity to return at some point during the season.
Source: http://www.detroitnews.com/article/20130810/SPORTS0101/308100059/1126/rss14
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Title: Sea Stars Underwater Offshore Northern California
Description:
Three sea stars on a rock, surrounded by a sandy seafloor littered with broken shells. Each sea star is approx. 10 - 15 cm (4-6 inches) across.?Image acquired 4.5 km (3 miles) offshore Pigeon Point, southern San Mateo County, California?at a depth of 52 meters.
Location: Pigeon Point, CA, USA
Date Taken: 9/28/2007
Photographer: USGS , USGS
Source:
Source:?California Seafloor Mapping Program Video and Photograph Portal? (Cruise ID F-3-07-NC, Track line 10, Image Number 1499, Depth 52.35. Lat 37.208847, Lon -122.454437)
?
?
File Details:
Type: JPEG image - 7.15 MB
Dimensions: 3306 x 2158
Suggest an update to the information/tags?
?
Source: http://gallery.usgs.gov/photos/08_08_2013_jOEq27Thg0_08_08_2013_1
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Photo by: Heather Coit/The News-Gazette
Nathan and Jenny Montgomery's home, the site of an 'Extreme Makeover: Home Edition' episode in 2009, as it appears now in Philo.
Image
PHILO ? Nearly four years after "Extreme Makeover: Home Edition" built the Montgomery family a new house in Philo, people still occasionally drive by to take a look at it.
Nathan Montgomery said he and his family just take it in stride.
There were only so many of these houses built, after all, and nobody has been overly intrusive, he said.
"For six months to a year, we'd have people driving by and taking pictures. It kind of just comes with the territory," Montgomery added. "The whole experience was such a blessing."
Here's an update on the family since the program aired in 2009:
Nathan Montgomery is still executive director of Salt & Light. His wife, Jenny, is a special education teacher at Homer Elementary School, and their four children are all students in Unit 7 schools.
Son Ashton, 17, will be a senior in the fall, and son Benjamin, who turns 13 on Monday, will be in the eighth grade. Daughter Addy, 9, is going into fourth grade, and daughter Lilly, 8, is going into the third grade.
The home that was built for the family and all the rooms inside are still pretty much exactly as the program designers and builders left them, Nathan Montgomery said.
But since the kids have gotten older, they have begun discussing making some changes.
Right after they moved in, "the kids said it felt like home right away," Montgomery recalled.
For him and his wife, it took "a little longer," he said.
One sad note: Both the family dogs, Rocky and Sampson, have died since the program aired.
Sampson was the large English mastiff that became the subject of much attention because he ran away while staying with relatives during the house build.
Sampson was found and returned the day after the house reveal, but he later developed bone cancer, Montgomery said. Rocky, a pug/Chihuahua mix, later developed severe arthritis.
"We've been dog-less since," he added.
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SYDNEY (Reuters) - The Australian Federal Police said on Wednesday they had arrested a man who they described as a senior member of the group that hacked websites of major corporations, including Sony Pictures, last year.
Police said the 24-year-old man, the self-styled leader of the LulzSec hacking collective, was charged on Tuesday with hacking offences.
LulzSec, an offshoot of the international hacking group Anonymous, has taken credit for hacking attacks on government and private sector websites, including 20th Century Fox and Nintendo.
Anonymous - and LulzSec in particular - became notorious in late 2010 when they launched what they called the "first cyber war" in retaliation for attempts to shut down the Wikileaks website.
(Reporting By Jane Wardell; Editing by Paul Tait)
This undated photo provided by Tom Smedinghoff, shows Anne Smedinghoff. Anne Smedinghoff, 25, was killed Saturday, April 6, 2013 in southern Afghanistan , the first American diplomat to die on the job since last year's attack on the U.S. diplomatic installation in Benghazi, Libya. (AP Photo/Tom Smedinghoff)
This undated photo provided by Tom Smedinghoff, shows Anne Smedinghoff. Anne Smedinghoff, 25, was killed Saturday, April 6, 2013 in southern Afghanistan , the first American diplomat to die on the job since last year's attack on the U.S. diplomatic installation in Benghazi, Libya. (AP Photo/Tom Smedinghoff)
This undated photo provided by Tom Smedinghoff, shows Anne Smedinghoff. Anne Smedinghoff, 25, was killed Saturday, April 6, 2013 in southern Afghanistan , the first American diplomat to die on the job since last year's attack on the U.S. diplomatic installation in Benghazi, Libya. (AP Photo/Tom Smedinghoff)
This image made from AP video shows Afghan National Army soldier rushing to the scene moments after a car bomb exploded in front the PRT, Provincial Reconstruction Team, in Qalat, Zabul province, southern Afghanistan, Saturday, April 6, 2013. Six American troops and civilians and an Afghan doctor were killed in attacks on Saturday in southern and eastern Afghanistan as the U.S. military's top officer began a weekend visit to the country, officials said. (AP Photo via AP video)
CHICAGO (AP) ? The family of an American diplomat who was among those killed in a terrorist attack in southern Afghanistan has taken solace in knowing she died doing what she loved.
Anne Smedinghoff, the first American diplomat to die on the job since last year's attack in Benghazi, Libya, was one of five Americans killed Saturday in a suicide car bombing while they were delivering textbooks to school children. The Taliban claimed responsibility for the attack.
The 25-year-old suburban Chicago woman was remembered as having a quiet ambition and displayed a love of global affairs from an early age. She joined the U.S. Foreign Service straight out of college and volunteered for missions in perilous locations worldwide.
"It was a great adventure for her ... She loved it," her father, Tom Smedinghoff, told The Associated Press on Sunday. "She was tailor-made for this job."
Anne Smedinghoff grew up in River Forest, Ill. ? an upscale suburb about 10 miles west of Chicago ? the daughter of an attorney and the second of four children. She attended the highly selective Fenwick High School, followed by Johns Hopkins University, where she majored in international studies and became a key organizer of the university's annual Foreign Affairs Symposium in 2008. The event draws high-profile speakers from around the world.
Those who knew Smedinghoff described her as a positive, hard-working and dependable young woman.
While a student in Baltimore, she worked part time for Sam Hopkins, an attorney near campus. He described her as ambitious "but in a wonderfully quiet, modest way."
Her first assignment for the foreign service was in Caracas, Venezuela, and she volunteered for the Afghanistan assignment after that. Her father said family members would tease her about signing up for a less dangerous location, maybe London or Paris.
"She said, 'What would I do in London or Paris? It would be so boring,'" her father recalled. In her free time, she would travel as much as possible, her father said.
Smedinghoff was an up-and-coming employee of the State Department who garnered praise from the highest ranks. She was to finish her Afghanistan assignment as a press officer in July. Already fluent in Spanish, she was gearing up to learn Arabic, first for a year in the U.S. and then in Cairo, before a two-year assignment in Algeria.
Secretary of State John Kerry said Sunday at a news conference in Turkey that Smedinghoff was "vivacious, smart" and "capable." Smedinghoff had assisted Kerry during a visit to Afghanistan two weeks ago.
He also described Smedinghoff as "a selfless, idealistic woman who woke up yesterday morning and set out to bring textbooks to school children, to bring them knowledge."
Her father said they knew the assignments were dangerous, though she spent most of her time at the U.S. Embassy compound. Trips outside were in heavily armored convoys ? as was Saturday's trip that killed five Americans, including Smedinghoff. The U.S. Department of Defense did not release the names of the others who died: three soldiers and one employee.
"It's like a nightmare, you think will go away and it's not," he said. "We keep saying to ourselves, we're just so proud of her, we take consolation in the fact that she was doing what she loved."
Friends remembered her Sunday for her charity work too.
Smedinghoff participated in a 2009 cross-country bike ride for The 4K for Cancer ? part of the Ulman Cancer Fund for Young Adults ? according to the group. She served on the group's board of directors after the ride from Baltimore to San Francisco.
"She was an incredible young woman. She was always optimistic," said Ryan Hanley, a founder of the group. "She always had a smile on her face and incredible devotion to serving others."
Johns Hopkins officials mourned her death in a letter on Sunday to students, faculty and alumni. Smedinghoff graduated in 2009. In the letter, University President Ronald J. Daniels praised her work on the symposium, her involvement in her sorority, Kappa Alpha Theta, and her involvement outside campus too.
"Her selfless action for others was nothing new," he wrote.
Funeral arrangements for Smedinghoff are pending.
___
Contact Sophia Tareen at https://www.twitter.com/sophiatareen .
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Alongside the big Facebook Home announcement today was a short and sweet video which ran through what these new Android apps were all about. Sure, the video is mostly about invoking all the feels for social networking, but we do get to see Chat Heads, Cover Feed and notifications in action. It looks like it's working smoothly enough, anyway.
Expect Facebook Home to be landing April 12, alongside the new HTC First.
| |
Source: http://feedproxy.google.com/~r/androidcentral/~3/leZeOah3mlw/story01.htm
In this April 3, 2013 photo shows Butte-Silver Bow Animal Shelter supervisor Jacki Casagranda sits with "Shirley" a pygmy goat in Butte Mont. The goat was picked up at a local bar by the animal warden last weekend. Fairmont Hot Springs Resort general manager Steve Luebeck says staffers knew the goat was missing but didn't realize it had been stolen until they saw a story in The Montana Standard reporting that a goat had been taken into a Butte bar early Sunday. Shirley was returned to the resort's petting zoo. (AP Photo/The Montana Standard, Walter Hinick)
In this April 3, 2013 photo shows Butte-Silver Bow Animal Shelter supervisor Jacki Casagranda sits with "Shirley" a pygmy goat in Butte Mont. The goat was picked up at a local bar by the animal warden last weekend. Fairmont Hot Springs Resort general manager Steve Luebeck says staffers knew the goat was missing but didn't realize it had been stolen until they saw a story in The Montana Standard reporting that a goat had been taken into a Butte bar early Sunday. Shirley was returned to the resort's petting zoo. (AP Photo/The Montana Standard, Walter Hinick)
BUTTE, Mont. (AP) ? So the goat that walked into a Montana bar last weekend ... was stolen from a petting zoo.
Fairmont Hot Springs Resort general manager Steve Luebeck says staffers knew the goat was missing but didn't realize it had been stolen until they saw a story in The Montana Standard on Wednesday reporting that a goat had been taken into a Butte bar early Sunday.
The pygmy goat, named "Shirley, was returned to the resort's petting zoo.
Luebeck tells The Standard (http://bit.ly/11rcGB5 ) he has never had an animal stolen from the zoo, which has goats and miniature horses. He says zoo managers would like to know who took the animal so they can press charges.
___
Information from: The Montana Standard, http://www.mtstandard.com
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![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 2-Apr-2013
Share ] Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
(SACRAMENTO, Calif.) A team of UC Davis scientists has found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease.
The scientists report their discovery in the Proceedings of the National Academy of Sciences (PNAS). The groundbreaking study was a collaboration among multiple UC Davis laboratories and Harvard University.
The metabolite is epoxy docosapentaenoic acid (EDP), an endogenous compound produced by the human body from the omega-3 fatty acid named docosahexaenoic acid (DHA), which is found in fish oil and breast milk. In animal studies, the UC Davis scientists found that EDP inhibits angiogenesis, the formation of new blood vessels in the body.
Tumors grow and spread by hijacking the normal biological process of angiogenesis, which plays a role in wound repair as well in growth and development. The UC Davis researchers determined that by inhibiting angiogenesis, EDP reduces the growth and spread (metastasis) of tumors in mice. The research provides the first scientific evidence about EDP's potent anti-cancer, anti-metastatic effects.
EDP works by a different mechanism than many current anti-cancer drugs that block angiogenesis.
"Our investigation opens up a new understanding of the pathways by which omega-3 fatty acids exert their biologic effects," said Guodong Zhang, the lead author of the article and a postdoctoral researcher in the laboratory of Bruce Hammock in the Department of Entomology and the UC Davis Comprehensive Cancer Center.
The researchers said that future studies hopefully will determine that stabilized EDP can be safely and effectively combined with other current anti-angiogenesis drugs in the treatment of cancer.
"As far as we know, EDPs are the first signaling lipids that have been discovered to have such potent anti-cancer effects. Researchers may be able to use EDPs as structural targets to develop stable analogs that mimic their anti-cancer agents," Zhang said.
"The study by Zhang and colleagues has uncovered a previously unrecognized anti-cancer effect of omega-3 fatty acids, which are an important lipid component of diets that have been developed to prevent heart disease and cancer," said Jonathan R. Lindner, professor of medicine at Oregon Health & Sciences University.
"The authors have demonstrated that metabolites of these lipids can act to suppress the growth of new blood vessels that are necessary to feed tumor growth," added Lindner, who was not involved in the study. "By shutting off a tumor's blood supply, these compounds can act to dramatically slow tumor growth and prevent spread. The results from this study suggest that new drug strategies for fighting cancer could emerge from knowledge of how the body uses nutrition to promote health."
The EDPs are broken down in the body by inhibiting the enzyme soluble epoxide hydrolase (sHI). In previous research, Hammock's lab showed that inhibitors of the sEHI enzyme help to normalize physiological activity. In the current study, UC Davis researchers determined that the addition of sEHI stabilized EDP in circulating blood thereby producing EDPs' anti-tumor effects. The anti-cancer drugs sorafenib and regorafenib are FDA-approved sEHIs.
"It may be possible to improve the efficacy of these anti-cancer drugs by combining them with a diet high in omega-3 and low in omega-6 fatty acids," Hammock said.
The researchers also found that a metabolite of arachidonic acid (ARA), an omega-6 fatty acid, has the opposite effect of EDP. The ARA metabolite, epoxyeicosatrienoic acids (EETs), slightly increases angiogenesis and tumor progression in mice.
"There is no free lunch," said Katherine W. Ferrara, professor in the UC Davis Department of Biomedical Engineering. "The EETs encourage wound healing, while the EDPs block the growth and metastasis of solid tumors.
"Our results designate EDPs and EETs as unique mediators of an angiogenic switch to regulate tumorigenesis," Ferrara said. "They also implicate a novel mechanistic linkage between omega-3 and omega-6 fatty acids and cancers."
UC Davis scientists determined that EDP starves tumors by inhibiting vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis in mice. In laboratory cultures, EDP also suppresses the endothelial cell migration needed for new blood vessels.
Thus, EDP-based angiogenesis inhibitors offer an advantage over angiogenesis inhibitors that target the VEGF-VEGFR2 pathway. The drugs that target the VEGF-VEFGFR2 pathway increase patients' risk for high blood pressure.
Because EDPs widen the blood vessels, a medication based on the UC Davis researchers' discovery should not increase the patient's risk for high blood pressure.
Harvard researchers Mark Kieran and Dipak Panigrahy conducted the metastasis studies. The in vivo imaging work that allowed the scientists to monitor tumors in living mice was done in Ferrara's UC Davis laboratory.
###
UC Davis Comprehensive Cancer Center is the only National Cancer Institute-designated center serving the Central Valley and inland Northern California, a region of more than 6 million people. Its specialists provide compassionate, comprehensive care for more than 9,000 adults and children every year, and access to more than 150 clinical trials at any given time. Its innovative research program engages more than 280 scientists at UC Davis, Lawrence Livermore National Laboratory and Jackson Laboratory (JAX West), whose scientific partnerships advance discovery of new tools to diagnose and treat cancer. Through the Cancer Care Network, UC Davis collaborates with a number of hospitals and clinical centers throughout the Central Valley and Northern California regions to offer the latest cancer care. Its community-based outreach and education programs address disparities in cancer outcomes across diverse populations. For more information, visit http://cancer.ucdavis.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 2-Apr-2013 Share ] Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
(SACRAMENTO, Calif.) A team of UC Davis scientists has found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease.
The scientists report their discovery in the Proceedings of the National Academy of Sciences (PNAS). The groundbreaking study was a collaboration among multiple UC Davis laboratories and Harvard University.
The metabolite is epoxy docosapentaenoic acid (EDP), an endogenous compound produced by the human body from the omega-3 fatty acid named docosahexaenoic acid (DHA), which is found in fish oil and breast milk. In animal studies, the UC Davis scientists found that EDP inhibits angiogenesis, the formation of new blood vessels in the body.
Tumors grow and spread by hijacking the normal biological process of angiogenesis, which plays a role in wound repair as well in growth and development. The UC Davis researchers determined that by inhibiting angiogenesis, EDP reduces the growth and spread (metastasis) of tumors in mice. The research provides the first scientific evidence about EDP's potent anti-cancer, anti-metastatic effects.
EDP works by a different mechanism than many current anti-cancer drugs that block angiogenesis.
"Our investigation opens up a new understanding of the pathways by which omega-3 fatty acids exert their biologic effects," said Guodong Zhang, the lead author of the article and a postdoctoral researcher in the laboratory of Bruce Hammock in the Department of Entomology and the UC Davis Comprehensive Cancer Center.
The researchers said that future studies hopefully will determine that stabilized EDP can be safely and effectively combined with other current anti-angiogenesis drugs in the treatment of cancer.
"As far as we know, EDPs are the first signaling lipids that have been discovered to have such potent anti-cancer effects. Researchers may be able to use EDPs as structural targets to develop stable analogs that mimic their anti-cancer agents," Zhang said.
"The study by Zhang and colleagues has uncovered a previously unrecognized anti-cancer effect of omega-3 fatty acids, which are an important lipid component of diets that have been developed to prevent heart disease and cancer," said Jonathan R. Lindner, professor of medicine at Oregon Health & Sciences University.
"The authors have demonstrated that metabolites of these lipids can act to suppress the growth of new blood vessels that are necessary to feed tumor growth," added Lindner, who was not involved in the study. "By shutting off a tumor's blood supply, these compounds can act to dramatically slow tumor growth and prevent spread. The results from this study suggest that new drug strategies for fighting cancer could emerge from knowledge of how the body uses nutrition to promote health."
The EDPs are broken down in the body by inhibiting the enzyme soluble epoxide hydrolase (sHI). In previous research, Hammock's lab showed that inhibitors of the sEHI enzyme help to normalize physiological activity. In the current study, UC Davis researchers determined that the addition of sEHI stabilized EDP in circulating blood thereby producing EDPs' anti-tumor effects. The anti-cancer drugs sorafenib and regorafenib are FDA-approved sEHIs.
"It may be possible to improve the efficacy of these anti-cancer drugs by combining them with a diet high in omega-3 and low in omega-6 fatty acids," Hammock said.
The researchers also found that a metabolite of arachidonic acid (ARA), an omega-6 fatty acid, has the opposite effect of EDP. The ARA metabolite, epoxyeicosatrienoic acids (EETs), slightly increases angiogenesis and tumor progression in mice.
"There is no free lunch," said Katherine W. Ferrara, professor in the UC Davis Department of Biomedical Engineering. "The EETs encourage wound healing, while the EDPs block the growth and metastasis of solid tumors.
"Our results designate EDPs and EETs as unique mediators of an angiogenic switch to regulate tumorigenesis," Ferrara said. "They also implicate a novel mechanistic linkage between omega-3 and omega-6 fatty acids and cancers."
UC Davis scientists determined that EDP starves tumors by inhibiting vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis in mice. In laboratory cultures, EDP also suppresses the endothelial cell migration needed for new blood vessels.
Thus, EDP-based angiogenesis inhibitors offer an advantage over angiogenesis inhibitors that target the VEGF-VEGFR2 pathway. The drugs that target the VEGF-VEFGFR2 pathway increase patients' risk for high blood pressure.
Because EDPs widen the blood vessels, a medication based on the UC Davis researchers' discovery should not increase the patient's risk for high blood pressure.
Harvard researchers Mark Kieran and Dipak Panigrahy conducted the metastasis studies. The in vivo imaging work that allowed the scientists to monitor tumors in living mice was done in Ferrara's UC Davis laboratory.
###
UC Davis Comprehensive Cancer Center is the only National Cancer Institute-designated center serving the Central Valley and inland Northern California, a region of more than 6 million people. Its specialists provide compassionate, comprehensive care for more than 9,000 adults and children every year, and access to more than 150 clinical trials at any given time. Its innovative research program engages more than 280 scientists at UC Davis, Lawrence Livermore National Laboratory and Jackson Laboratory (JAX West), whose scientific partnerships advance discovery of new tools to diagnose and treat cancer. Through the Cancer Care Network, UC Davis collaborates with a number of hospitals and clinical centers throughout the Central Valley and Northern California regions to offer the latest cancer care. Its community-based outreach and education programs address disparities in cancer outcomes across diverse populations. For more information, visit http://cancer.ucdavis.edu.
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Source: http://www.eurekalert.org/pub_releases/2013-04/uoc--fam040213.php
Flurry, an app analytics firm with a presence on some now 1 billion mobile devices, has taken another deep dive into its large data set to examine the increasingly fragmented selection of hardware form factors on the market today, in an effort to better understand consumer preferences. The report concludes that people most prefer and use apps on medium-sized smartphones, like those in the Samsung Galaxy line, and full-sized tablets like the iPad. "Phablets," meanwhile, Flurry dubs a "fad," saying that they don't show significant, or even disproportionally significant, app usage.Source: http://feedproxy.google.com/~r/Techcrunch/~3/kU9AR-YSoQo/
LONDON (AP) ? Stock markets mostly rose on Tuesday on hopes that improvements in the U.S. economy will make up for the continued gloom in the eurozone, where the unemployment rate hit a new record high.
Traders will keep an eye on data for U.S. factory orders later Tuesday in the run-up to Friday's release of the monthly jobs figures, a key measure of the health of the world's largest economy.
The steady recovery in the U.S. has been supporting markets in the face of financial trouble in the 17-country eurozone, where the economy continues to wilt under the pressure of government budget cuts. Unemployment in the single currency bloc hit a record high in January and February, at 12 percent. Governments are trimming costs and companies are discouraged from hiring due to uncertainty in markets.
Cyprus was the focus of such financial uncertainty this month as it chaotically negotiated a bailout. Deep cuts to its banking sector are expected to cause a huge slump in the economy ? to ease the pain the country was granted more time to reach its budget targets.
By late morning in Europe, Britain's FTSE 100 was up 0.8 percent to 6,465.73 while Germany's DAX rose 0.7 percent to 7,849.30. France's CAC-40 rose 0.6 percent to 3,754.26.
Wall Street also appeared headed for gains, with Dow Jones industrial futures rising 0.3 percent to 14,525. The broader S&P 500 futures gained 0.3 percent to 1,560.70.
Earlier, Japan's Nikkei 225 tumbled 1.1 percent to close at 12,003.43 as the yen's recent weakness reversed course. A stronger currency makes products sold abroad more expensive, a hardship for Japan's export-dependent economy.
Analysts said, however, that the new government in Japan, with its new plan of attack to right the country's economy, has lifted business optimism. A survey released by the Bank of Japan on Monday showed an improvement in business sentiment, although it was smaller than expected.
"The economy is improving, albeit slowly, and the mood has been lifted by the assertive and coordinated economic plan of the new government," Moody's Analytics said in a market commentary.
Hong Kong's Hang Seng closed 0.3 percent higher at 22,367.82.
Australia's S&P/ASX 200 advanced 0.4 percent to 4,985.50. South Korea's Kospi opened higher but then gave up its gains by midday. It was 0.5 percent down at 1,986.15. Benchmarks in mainland China, the Philippines and New Zealand also fell.
In commodity markets, the benchmark oil contract for May delivery was up 8 cents to $97.15 per barrel in electronic trading on the New York Mercantile Exchange. The contract fell 16 cents on Monday.
In currencies, the euro rose to $1.2838 from $1.2804 late Monday in New York. The dollar fell to 93.31 yen from 94.22 yen.
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Pamela Sampson in Bangkok contributed to this report.
Source: http://news.yahoo.com/world-stocks-edge-higher-us-economy-hopes-102721813--finance.html
By Alan Wheatley and Daniel Alvarenga
TORRES VEDRAS, Portugal (Reuters) - For Portugal to succeed in ambitions to reindustrialize its shrinking, debt-laden economy, it will not be down to the revival of mass manufacturing but to the sprouting of high-tech start-ups such as UAVision.
As the name Unmanned Aerial Vehicles suggests, drones mounted with cameras are a mainstay for the small engineering firm. Clients include big farmers who want to monitor conditions in their fields. One drone has been adapted to film camel racing in Dubai.
Nuno Simoes, one of UAVision's partners, is as excited as a schoolboy as a small battery-driven drones lifts off outside his workshops some 55 km (35 miles) north of Lisbon.
He says Portugal needs to play to its strengths in design and engineering rather than making eyes at footloose multinationals.
"Don't think big. We are a small country with small companies," Simoes said. "They think they can turn Portugal into a new European China. They can't. China can produce at a fraction of our cost."
Ground down by deep public spending cuts and shrinking domestic demand under an austerity program imposed by international lenders, the Portuguese economy contracted 3.2 percent in 2012 and is expected to shrink by a further 2.3 percent this year.
It grates with Economy Minister Alvaro Pereira that Portugal has lost too many jobs and industries to the likes of China and eastern Europe.
Manufacturing accounts for about 13.5 percent of national output. That is more than in Britain and the Netherlands, but Pereira would like to get the share back to 20 percent, where it stood in 1989, by 2020.
"One of the problems that we've had in Europe in the last few years was to think that investing in industry was not sexy," Pereira said in London recently. "We don't need to bring back all our industry, but we definitely need to have a stronger industrial base in Europe."
He rejects old-style industrial policies and focuses instead on improving conditions for manufacturing, such as by expanding vocational training.
The odds are against Pereira. Too many older workers lack skills, which weighs on competitiveness. Businessmen complain that the government ties them up in red tape. And credit is hard to come by.
"The banks give you an umbrella when the sun's shining and take it away when it's raining," grumbles Joao Carlos Costa, general manager of Arpial, a small metal-working firm in Lisbon.
But Joachim Fels, chief international economist with Morgan Stanley in London, said there are signs that production is returning to countries such as Portugal as labor costs in emerging markets rise.
"The interesting thing is that globalization is not a one-way street," he said.
HIGH-TECH, DESIGNER-DRIVEN
An illustration of that phenomenon is Brazilian plane maker Embraer, which has built a components factory in the walled Roman town of Evora to tap Portugal's underused aeronautical engineering skills.
Successful collaboration with Embraer not only will demonstrate that Portugal is capable of high-tech innovation but also will help change the nation's mindset, said Jacinto Moniz de Bettencourt, chairman of EEA, a group of 35 suppliers to the Brazilian company.
"We are capable now of making some products that 10 or 20 years ago we wouldn't have believed we could do," he said.
Just one example: the trunks worn at the London Olympics by Michael Phelps and other star swimmers were designed and made in Portugal.
The textile industry is not the only traditional sector striving to reinvent itself. Renova, Portugal's leading producer of paper goods, makes a black lavatory tissue that is much coveted. Portuguese shoe makers insist their wares are now as prized as Italy's.
"Portugal has to rebuild its image. If you go to Germany and try to sell a product or a service and say it's from Portugal, it's associated with low technology and low quality," said Antonio de Melo Pires, the head of Volkswagen AutoEuropa, the country's second-biggest exporter.
Pires, too, sees no comparative advantage in trying to lure mass manufacturing. Instead, Portugal should boost its shipping and logistics industries to capitalize on its relative proximity to Africa and the Americas, he said.
A cut in the 25 percent corporate tax rate would also encourage more firms to set up shop in Portugal, Pires added.
"We have to attract middle-sized companies because they are more flexible, they require less investment and so they distort the regional economy less," he said.
Of course, competition for foreign direct investment is stiff.
Steiff, the German maker of expensive teddy bears, recently closed a factory in the central town of Oleiros with the loss of 100 jobs. It shifted production to Sidi Bouzid, Tunisia, the birthplace of the Arab Spring uprising in late 2010.
"Salaries in Tunisia are less than half those in Portugal, so that was the key problem," Jose Marques, the mayor of Oleiros said. "This was pure greed. I see no other reason."
Sara Ladeira, a seamstress for 12 years at the Oleiros plant, earned Portugal's minimum wage of 485 euros ($620) a month. Ladeira, 33, with two children, worries how she and her husband will pay the mortgage now that she is out of a job.
"It was a surprise to us all, because we had a lot of work to do at the factory," she said.
Armenio Carlos, the head of the CGTP union, Portugal's largest, says the ambition to revive industry is realistic. But he is critical of the government for acting too late, lacking a strategic vision and failing to finance its plans.
"One of the big problems we have is that after we joined the EU we allowed industry to crumble. We were relegated almost completely to being a country of services," Carlos, a former electrician, said in an interview.
One of the entrepreneurs trying to reverse that trend echoes the union leader. "We cannot just live off sun and olive oil," said Antonio Reis, technical director with Optimal Structural Solutions, a design and engineering start-up.
"Is our economy sustainable only on tourism? I don't think it is, so we have to grow industrially."
($1 = 0.7788 euros)
(editing by Jane Baird)
Source: http://news.yahoo.com/analysis-easier-said-done-portugal-revive-industry-141353258--sector.html
As per usual, Google put out various, elaborate April Fools Day jokes, which only reminded everyone how much time and money the tech company has to spend on projects that aren't core products like, ahem, Google Reader.?For those too busy to follow along, The Next Web has a running list of the myriad pranks. And while some of the antics, like the pirate treasure map,?are harmless and cute, others hit too close to home.
Source: http://news.yahoo.com/mass-gas-prices-down-another-173139893.html
UFC 150 Caster Semenya Medal Count 2012 Olympics victoria beckham
Apr. 1, 2013 ? A new study by Los Alamos National Laboratory and University of Pennsylvania scientists defines previously unknown properties of transmitted HIV-1, the virus that causes AIDS. The viruses that successfully pass from a chronically infected person to a new individual are both remarkably resistant to a powerful initial human immune-response mechanism, and they are blanketed in a greater amount of envelope protein that helps them access and enter host cells.
These findings will help inform vaccine design and interpretation of vaccine trials, and provide new insights into the basic biology of viral/host dynamics of infection.
During the course of each AIDS infection, the HIV-1 virus evolves within the infected person to escape the host's natural immune response and adapt to the local environment within the infected individual. Because HIV evolves so rapidly and so extensively, each person acquires and harbors a complex, very diverse set of viruses that develops over the years of their infection. Yet when HIV is transmitted to a new person from their partner, typically only a single virus from the diverse set in the partner is transmitted to establish the new infection.
The key discoveries here are the specific features that distinguish those specific viruses which successfully move to the new host, compared with the myriad forms in the viral population present in a chronically infected individual.
"The viruses that make it through transmission barriers to infect a new person are particularly infectious and resilient," said Los Alamos National Laboratory scientist Bette Korber. "Through this study we now better understand the biology that defines that resilience."
The team set out to determine whether the viruses that were successfully transmitted to a new patient might share distinct biological properties relative to those typically isolated from people with long-term, chronic infection. To do this, the group at U Penn cloned a set of intact viruses from acute infection, and a set of viruses from chronically infected people, and characterized them by measuring quantities that might be related to the virus's ability to successfully establish a new infection. They discovered several clear correlations. For example, transmitted viruses were both more infectious and contained more protective "envelope" per virus; envelope is the protein the virus uses to enter host cells.
The team identified an additional interesting property that could be a general characteristic of new viral infections: the transmitted HIV was capable of replicating and growing well in the presence of alpha interferon. Alpha interferon production is part of our innate human immune response to a new infection. As soon as a new viral infection is initiated in our bodies, local immune cells at the site of infection start secreting molecules called cytokines that have general antiviral activity and can inhibit the production of the newly infected virus. Alpha interferon is one of these potent cytokines.
In the early days of an HIV infection, this innate immune response increases to an intense level, called a "cytokine storm," which gradually recedes during infection. For a newly transmitted HIV to successfully establish infection, it must grow and expand in the new host while facing this cytokine storm. Although typical chronic viruses are sensitive to and inhibited by alpha interferon, transmitted HIV-1 viruses grew well in the presence of interferon.
Los Alamos scientists Elena Giorgi, James Theiler and Bette Korber were part of the analysis team working closely with investigators at the University of Pennsylvania, Nick Parrish and Beatrice Hahn. The paper, "Phenotypic properties of transmitted founder HIV-1" is in this week's issue of Proceedings of the National Academy of Sciences.
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ROME (AP) ? Pope Francis reached out in friendship to "so many Muslim brothers and sisters" during a Good Friday procession dedicated to the suffering of Christians from terrorism, war and religious fanaticism in the Middle East.
The new pontiff, who has rankled traditionalists by rejecting many trappings of his office, mostly stuck to the traditional script during the nighttime Way of the Cross procession at Rome's Colosseum, one of the most dramatic rituals of Holy Week.
With torches lighting the way, the faithful carried a cross to different stations, where meditations and prayers were read out recalling the final hours of Jesus' life and his crucifixion.
This year, the prayers were composed by young Lebanese, and many recalled the plight of minority Christians in the region, where wars have forced thousands to flee their homelands. The meditations called for an end to "violent fundamentalism," terrorism and the "wars and violence which in our days devastate various countries in the Middle East."
Francis, who became pope just over two weeks ago, chose, however, to stress Christians' positive relations with Muslims in the region in his brief comments at the end of the ceremony.
Standing on a platform overlooking the procession route, Francis recalled Benedict XVI's 2012 visit to Lebanon when "we saw the beauty and the strong bond of communion joining Christians together in that land and the friendship of our Muslim brothers and sisters and so many others."
"That occasion was a sign to the Middle East and to the whole world, a sign of hope," he said.
Friday's outreach followed Francis' eyebrow-raising gesture a day earlier, when he washed and kissed the feet of two women, one a Muslim, in the Holy Thursday ritual that commemorates Jesus' washing of his apostles' feet during the Last Supper before his crucifixion.
Breaking with tradition, Francis performed the ritual on 12 inmates at a juvenile detention center, rather than in Rome's grand St. John Lateran basilica, where in the past, 12 priests have been chosen to represent Jesus' disciples.
Before he became pope, the former Cardinal Jorge Mario Bergoglio long cultivated warm relations with Muslim leaders in his native Argentina. In one of his first speeches as pope, he called for the church and the West in general to "intensify" relations with the Muslim world.
The Vatican's relations with Islam hit several bumps during Benedict XVI's papacy, when he outraged Muslims with a 2006 speech quoting a Byzantine emperor as saying some of Prophet Muhammad's teachings were "evil and inhuman." And in 2011, the pre-eminent institute of Islamic learning in the Sunni Muslim world, Cairo's Al-Azhar institute, froze dialogue with the Vatican to protest Benedict's call for greater protection of Christians in Egypt.
However, Francis' past outreach to the Muslim community in Argentina seems to have changed that. Al-Azhar's chief imam, Sheik Ahmed el-Tayyib, sent a message of congratulations to Francis on his election and said he hoped for cooperation.
The Vatican's efforts to reconcile with the Islamic world have not been welcomed by all. Italy's most famous Muslim convert to Catholicism, Magdi Allam, announced last week he was leaving the church because of its "soft" stance on Islam. Allam was baptized by Benedict XVI in 2008 during the high-profile Easter Vigil service when the pope traditionally baptizes a handful of adults. There has been no Vatican comment on his about-face.
Thousands of people packed the Colosseum and surrounding areas for the nighttime procession, holding candles wrapped in paper globes as Francis sat in silent prayer as a giant torch-lit crucifix twinkled nearby. Some in the crowd had Lebanese flags around their shoulders in an indication of the special role Lebanese faithful played in this year's procession.
Lebanon has the largest percentage of Christians in the Middle East ? nearly 40 percent of the country's 4 million people, with Maronite Catholics the largest sect. As civil war has raged in neighboring Syria, Lebanon's Christian community has been divided between supporters and opponents of Syrian President Bashar Assad.
Overall, Christians in the Middle East have been uneasy as the Arab Spring has led to the strengthening of Islamist groups in most countries that have experienced uprisings. Thousands of Christians have fled the region ? a phenomenon that the Vatican has lamented, given Christianity's roots in the Holy Land.
"How sad it is to see this blessed land suffer in its children, who relentlessly tear one another to pieces and die!" said one of the Good Friday meditations. "It seems that nothing can overcome evil, terrorism, murder and hatred."
Francis picked up on that message, saying Christ's death on the cross is "the answer which Christians offer in the face of evil, the evil that continues to work in us and around us."
"Christians must respond to evil with good, taking the cross upon themselves as Jesus did," he said.
At the end of the ceremony, a male choir sang a haunting Arabic hymn, a reflection of the Eastern rite influence that infused the ceremony.
On Saturday, Francis presides over the solemn Easter Vigil ceremony in St. Peter's Basilica and on Sunday, he celebrates Easter Mass and delivers an important speech. Usually the pope also issues Easter greetings in dozens of languages.
In his two weeks as pope, Francis' discomfort with speaking in any language other than Italian has become apparent. The Vatican spokesman, the Rev. Federico Lombardi, said Friday "we'll have to see" what Francis does with the multilingual greetings.
The Good Friday procession was conducted entirely in Italian, whereas in years past the core elements recounting what happens at each station would be recited in a variety of languages.
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Follow Nicole Winfield at www.twitter.com/nwinfield
Source: http://news.yahoo.com/pope-refers-muslim-brothers-good-friday-001145243.html
